Transfer Factors – Real Immune Support Backed by Science & 4Life

Imagine the very first milk a newborn receives from its mother. It’s no ordinary nourishment. Within this precious substance lies a tiny but mighty army of molecules called Transfer Factors, nature’s immune system tutors. These molecules train a baby’s immune system to quickly recognize, respond to, and remember health threats. What’s even more incredible? These immune trainers are found not only in humans but across all mammals, and remarkably, they are fundamentally the same across species.

In 1949, Dr. H. Sherwood Lawrence, an immunologist at New York University, discovered that immune responses could be transferred from one person to another using an extract from white blood cells, leading him to the term “Transfer Factor.” *read the transfer factor summary written by H.S Lawrence here*

Decades later in 1997, 4Life Research founder David Lisonbee came across a patent for extracting transfer factors from cow colostrum. Intrigued, he licensed the patent and soon launched 4Life Transfer Factor Classic,the first supplement of its kind.

Transfer Factors: The Science Behind Immune Education

Transfer Factors are tiny peptides (≤12 kDa), known for their ability to transfer immunity from one individual to another. Their core function is to guide immune cells through a three-step process: recognizing threats, responding swiftly, and remembering invaders for faster future defense.

Scientific research, including a 2022 double-blind, placebo-controlled trial, shows that 4Life’s Transfer Factor formulas can activate the immune system within just two hours. Independent labs confirm that these molecules enhance natural killer (NK) cell activity, increase secretion of key immune signaling molecules like interferon-gamma (IFN-γ) and granzyme B, and balance adaptive immunity by promoting helpful Th1 cytokines while reducing excessive Th2 and Th17 responses. Physicians' Desk Reference. (n.d.). 4Life Transfer Factor. PDR.net. Retrieved June 15, 2025, from

Key Research Supporting Transfer Factors

Multiple peer-reviewed studies validate the immune-enhancing effects of Transfer Factors:

• Immune Activation in Healthy Adults (2023): A placebo-controlled study showed that a single dose of 4Life Transfer Factor Tri-Factor formula significantly increased immune cells such as monocytes, natural killer (NK) cells, and natural killer T (NKT) cells within two hours, while reducing inflammatory markers like IL-6 and IFN-γ.
  Source

• Enhancement of Cellular and Humoral Immunity (2020): Animal studies demonstrated that Transfer Factors modulate both the cellular (T cells, NK cells) and humoral (antibody) branches of the immune system, improving responses to pathogens.
  Vetvicka et al., International Clinical Pathology Journal

• Adjunct Therapy for Infectious Diseases (2013): Transfer Factors were shown to be effective as adjunct immunotherapy in viral, bacterial, and fungal infections, including potential benefits in tuberculosis and herpes virus management.
  Viza et al., Folia Biologica

• Modulating Immune Balance in Allergies (2010): Research suggests Transfer Factors may restore the Th1/Th2 cytokine balance, which is crucial in managing allergic responses.
  Vera et al., Revista Alergia Mexico

• Support for Autoimmune Conditions and Cancer (Multiple studies): Clinical and experimental trials indicate Transfer Factors can support immune regulation in autoimmune diseases and enhance cell-mediated immunity against tumors.
  Vetto et al., Cancer (1976) | Frith et al., Clinical and Experimental Neurology (1986)

While many of these studies highlight promising results, it’s important to note that some involve small sample sizes or animal models, and ongoing research is needed to fully understand long-term effects.

Safety and Regulatory Considerations

Unlike older transfer factor sources derived from blood or spleen, carrying potential pathogen risks. 4Life’s colostrum- and egg yolk-based products avoid these issues entirely. Clinical trials and usage reports show high safety margins and no significant adverse effects. However, it’s important to remember these products are classified as dietary supplements, not FDA-approved drugs, and are intended to support, not replace medical treatments.

Strengths and Limitations

The compelling aspect of Transfer Factors lies in their rapid immune activation, supported by both human and animal research. 4Life’s patented extraction methods and peer-reviewed lab data add scientific credibility. Yet, many studies so far involve small participant numbers or short-term use. Some research has also been funded by supplement companies, which calls for independent validation in future studies.

The Immune System: Your Key to Healthy Aging

Why is this so important? Our immune systems naturally weaken as we age, affecting not only our ability to fight infections but also influencing the biological aging process itself. Studies show that the strength of your immune system often correlates more closely with your biological age than your chronological birthdate. A robust immune system means better health, vitality, and longevity. Transfer Factors may play a crucial role in maintaining this immune vitality throughout life.

In Conclusion: A Natural Immune Classroom

From their discovery in mid-20th century blood extracts to today’s sophisticated colostrum and egg formulas, Transfer Factors offer a unique bridge between natural immune wisdom and modern science. 4Life’s narrative of “Recognize, Respond, Remember” resonates in the growing body of evidence showing rapid immune activation. While cautious experts await larger clinical trials, Transfer Factors stand as a promising immune adjunct—teaching your immune system how to defend and remember, much like the first gift a newborn receives from its mother.